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, 1994). CoVs genomic RNA replication is mediated by RNA-directed RNA polymerase (Pol/RdRp) that's also accountable for transcription on the viral RNA genome. There is experimental proof for SARS-CoV that nsp7 and nsp8 activate and confer processivity towards the RNA-synthesizing exercise of your polymerase (partitions et al., 2000). The synthesis